Synthesis of Multiply Arylated Pyridines

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Synthesis of Multiply Arylated Pyridines
Asako, T.; Hayashi, W.; Suzuki, S.; Amaike, K.; Itami, K.; Muto, K.; Yamaguchi, J.¥
Tetrahedron 2017, 73, 3669-3676 (Invited contribution).
DOI: 10.1016/j.tet.2017.03.095

We have achieved a synthesis of multiply arylated pyridines by using a [4+2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross-couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents.

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