Synthesis of A Heptaarylisoquinoline: Unusual Disconnection for Constructing Isoquinoline Frameworks

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Asako, T.; Suzuki, S.; Itami, K.; Muto, K.; Yamaguchi, J.
Chem Lett. 2018, Advanced Publicatiion
DOI 10.1246/cl.180429
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In a novel disconnection of isoquinoline ring synthesis at the C7–C8/C4a–C8a bonds, these bonds can be formed by a [4+2] cycloaddition between thiophene S,S-dioxide and alkynes. With a subsequent C–H arylation of the resulting hexaarylisoquinoline at the C3 position, the synthesis of a fully substituted isoquinoline has been achieved.

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