Development and Elucidation of the Ni-Catalyzed Direct Coupling Reaction

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Yamaguchi, J.*; Muto, K.; Itami, K.

Nickel catalysis for biaryl coupling reactions has received significant attention as a less expensive and less toxic alternative to “standard” palladium catalysis. Here we describe recent our developments in nickel-methodology, along with mechanistic studies and applications. In particular we focus on nickel-catalyzed coupling reactions in which “unreactive” bonds such as C–H, C–O, and C–C bonds are converted into biaryl moieties. catalyzed bialy coupling.

Chemical Times, (Japanese account) 2016, 1–7. [Link]

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