Denitrative Mizoroki–Heck Reaction

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Palladium-Catalyzed Mizoroki−Heck Reaction of Nitroarenes and Styrene Derivatives
Okita, T.; Asahara, K. K.; Muto, K.; Yamaguchi, J.
Org. Lett. 2020 ,ASAP. DOI: 10.1021/acs.orglett.0c00983

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.

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