Aryl Dance Reaction of Arylbenzoheteroles

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Aryl Dance Reaction of Arylbenzoheteroles
Nakahara, H; Yamaguchi, J.
Org. Lett. 2022, ASAP.
DOI 10.1021/acs.orglett.2c03442

We report a 1,2-migration (aryl dance reaction) of the aryl group on heteroles. AlCl3 can efficiently convert C3-arylheteroles to C2-arylheteroles. Depending on the electron density of the substrate, conversion from C2- to C3-arylheteroles was also possible with catalytic Zn(OTf)2. A one-pot aryl dance/acylation or bromination and arylation/aryl dance cascade was also demonstrated.

 

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